منابع مشابه
This Week in The Journal
Opioid drugs and our brain’s endogenous opioids work primarily at mu-type opioid receptors ( R) to dampen pain signals. But because the R is expressed throughout the brain and body, R agonists can cause side effects ranging from constipation to addiction. The related delta-type opioid receptor ( R), in contrast, has more limited expression, but it is found in nociceptive sensory neurons, making...
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Most neurons in the external segment of the globus pallidus (GPe) contribute to the indirect pathway from the dorsal striatum to the output nuclei of the basal ganglia, relaying information from the striatum to the subthalamic nucleus. But 25% of GPe neurons project back to the striatum. These neurons, called arkypallidal neurons, were recently proposed to cancel movements that are in the prepa...
متن کاملThis Week in The Journal
Rather than being distributed evenly throughout the plasma membrane, cellular signaling proteins are concentrated in lipid rafts, which are enriched in sphingolipids and cholesterol. Lipid rafts are particularly dense in neuronal membranes, as are their associated signaling proteins, which direct neuronal differentiation. Palmitoylated proteins aggregate in the detergent-resistant membrane (DRM...
متن کاملIs this journal really needed?
D uring the second world war, propaganda posters carried a message that asked, ''Is this trip really necessary?'' Their purpose was to persuade people to conserve gasoline. Prompted by the decision to limit free online access to subscribers, some board members and I examined the role this journal plays in fostering injury prevention internationally. We asked, in effect, if this journal was real...
متن کاملThis Week in The Journal
When an action potential enters a synaptic terminal, voltage-gated calcium channels open, allowing calcium ions to enter and promote synaptic vesicle release. How many vesicles are released depends on the number of release sites and the density and location of calcium channels. If channels are close to release sites, incoming ions quickly bind to vesicle-associated calcium sensors, and relative...
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ژورنال
عنوان ژورنال: Canadian Psychiatric Association Journal
سال: 1962
ISSN: 0008-4824
DOI: 10.1177/070674376200700612